❇️ انتشار #مقاله جدید با وابستگی کوتار💠 Global research trends on systemic lupus erythematosus and thyroid cancers (1964-2023): A scientometric and visualized study👥 Hediyeh Alemi, Naghmeh Khavandgar, Iman Menbari Oskouie, Heydar Ali Mardani-Fard, Tahereh Rostami, Azadeh AleTaha, Niloofar Peykari, Majid Alikhani, Sayed Mahmoud Sajjadi-Jazi, Amir Kasaeian*, Shirin Djalalinia, Akbar Soltani

📔 Medicine (Q2)

🗓 June 2024🗂 Review📄 Abstract: Over the past 3 decades numerous studies have reported an association between systemic lupus erythematosus (SLE) and thyroid cancers. However, there has been no scientometric analysis in this area of research. To perform a comprehensive scientometric analysis of the global literature published on the association between SLE and thyroid cancers. The data on publications within thyroid cancers in SLE patients were retrieved from the Scopus database using a defined search strategy from its first publication in 1964 to 2023. To conduct a collaboration mapping analysis among keywords, authors, journals, and territories, VOSviewer was utilized. Our final research resulted in 246 scientific publications with 8072 citations, which were published in 198 journals affiliated to 48 countries. A global upward trend has been observed in the last 20 years, with the highest number of publications in the year 2022 (n = 28; 11.4%). The United States led the global productivity ranking with 74 publications (30.1%), followed by China with 25 publications (10.2%). The most popular journals in this field were "Arthritis Research and Therapy" and "Frontiers in Endocrinology," while the most co-cited journal was "Autoimmunity Reviews." The top 3 most prolific authors were Bernatsky, S., Clarke, A.E., and Ramsey-Goldman, R with 9 publications each. This first scientometric study comprehensively offered an overview of the status of thyroid cancers in SLE patients, assessing scholarly productivity in this domain over a period of 50 years.

🔗 https://dx.doi.org/10.1097/MD.0000000000038511

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❇️ انتشار #مقاله جدید با وابستگی کوتار💠 Proximal femoral varus osteotomy for Legg–Calvé–Perthes disease: Do age and lateral pillar classifications influence short-to-mid-term clinical and radiological outcomes?👥 Nima Hoseini-Zare, Peyman Mirghaderi, Brice Ilharreborde, Kiarash Roustai-Geraylow, Alireza Moharrami, Taghi Baghdadi, Seyed Hadi Kalantar, Mohammad Hossein Nabian

📔 Orthopaedics & Traumatology: Surgery & Research (Q1)

🗓 May 2024🗂 Original research📄 Abstract: Proximal femoral varus osteotomy (FVO) is one of the most used treatment methods with acceptable outcomes for Legg–Calvé–Perthes disease (LCPD). We aimed to investigate the influence of age at disease onset and the Lateral Pillar classification on clinical and radiological outcomes of FVO surgery LCPD patients between 6–12 years of age. Proximal FVO surgery in the early fragmentation phase of LCPD patients led to acceptable clinical and radiographic outcomes in a 3-year follow-up, regardless of preoperative age and Herring type. Fifty patients with LCPD (Herring groups B, B/C, and C) who underwent FVO were retrospectively reviewed. We evaluated radiological [center-edge angle, extrusion index, epiphyseal index, acetabular index, articulo-trochanteric distance (ATD)] and clinical [hip abduction range of motion (ROM), Trendelenburg sign, pain, and Harris hip score (HHS)] outcomes with a follow-up of 37.3 ± 10.5 months (range: 24–180 months). Finally, the overall treatment outcome was assessed using the Stulberg classification. The ROC curve analysis did not reveal any significant relationship between age and clinical or radiological outcomes, and there was no predictable age cut-off for surgical outcomes (p = 0.13). No significant difference was found in Stulberg classification at the follow-up between patients with type B, B/C, and C of the lateral pillar (p > 0.05). Our results demonstrated that open-wedge proximal FVO surgery in the early fragmentation phase of LCPD patients led to acceptable clinical and radiographic outcomes in a 3-year follow-up. Each sample of our study was very small and a lot of variables were measured, making this result not adequately strong enough to draw a robust conclusion. However, FVO surgery remains a possible suggestion for patients in the early fragmentation phase, and age and lateral pillar type may not be limiting factors.

🔗 https://doi.org/10.1016/j.otsr.2024.103909

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❇️ انتشار #مقاله جدید با وابستگی کوتار💠 Biomechanical Study of Using Patient-Specific Diaphyseal Femoral Cone in Revision Total Knee Arthroplasty (rTKA)👥 Reza Nourishirazi, Ghazaleh Moradkhani, Arash SharafatVaziri, Hamidreza Nematy, Ramin Shayan-moghadam, Morad Karimpour

📔 Journal of Orthopaedics (Q3)

🗓 June 2024🗂 Original research📄 Abstract: The primary objective of revision total knee surgery is to achieve solid bone fixation. Generally, this could be accomplished using sleeves and long stems, which require substantial remaining bone stock and may increase the risk of stem tip pain. An alternative approach involves the use of customized diaphyseal cones, which can preserve the integrity of the bone canal. This study evaluates the impact of employing femoral diaphyseal cones with various stem lengths on stress distribution and relative motion. CT scan data from five patients were used to generate the 3D model of the femur, cement, customized stems, and cones, along with assigning patient-specific material for each candidate’s femur. Three different stem lengths, both with and without the customized cone, were assessed under three gait loading conditions to compare the resulting Von Mises stress distribution and relative motion. Analysis indicated that the use of customized femoral cones moderately increases stress distribution values up to 30 % while significantly reducing relative motion at the femoral canal-cone interface by nearly 60 %. The presence of the cone did not significantly alter relative motion with varying stem lengths, although stem length variation without a cone substantially affected these values. Incorporating cones alongside stems enhances metaphyseal fixation, reduces stress shielding, potentially allowing for the use of shorter stems. Furthermore, cones promote osseointegration by minimizing relative motion, ultimately improving prosthetic stability.

🔗 https://doi.org/10.1016/j.jor.2024.06.002

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❇️ انتشار #مقاله جدید با وابستگی کوتار💠 Genetic and Lifestyle Risk Factors of Metabolic Dysfunction-Associated Fatty Liver Disease and Its Relationship with Premature Coronary Artery Disease: A Study on the Pars Cohort👥 Amir Anushiravani, Maryam Rayatpisheh, Amir Kasaeian, Iman Menbari Oskouie

📔 Archives of Iranian Medicine (Q1)

🗓 May 2024🗂 Original research📄 Abstract: The main objective of this study is to identify the risk factors of metabolic dysfunction-associated fatty liver disease (MAFLD) in coronary artery disease (CAD) patients. The present retrospective cohort study is part of the Pars Cohort Study (PCS). The participants were categorized as having MAFLD or not. The pattern of independent variables in patients was compared with those who did not have MAFLD. All variables were retained in the multivariable logistic regression model. Totally, 1862 participants with CAD were enrolled in this study. MAFLD was diagnosed in 647 (40.1%) participants. Gender, diabetes, hypertension, tobacco, opium, alcohol, age, weight, waist circumference, cholesterol, HDL, triglyceride, aspartate aminotransferase (AST), and alanine aminotransferase (ALT) were significantly different in MAFLD and non-MAFLD patients. Also, the results of multivariable logistic regression show male gender (OR=0.651, 95% CI: 0.470‒0.902, P value=0.01) and opium consumption (OR=0.563, 95% CI: 0.328‒0.968, P value<0.001) to be negative risk factors of MAFLD occurrence in CAD patients. Having diabetes (OR=2.414, 95% CI: 1.740-3.349, P value<0.001), high waist circumference (OR=1.078, 95% CI: 1.055‒1.102, P value<0.01), high triglyceride (OR=1.005, 95% CI: 1.001‒1.008, P value=0.006), and high ALT (OR=1.039, 95% CI: 1.026‒1.051, P value<0.01) were positive risk factors of MAFLD in CAD patients. Our study found that consuming opium decreases the likelihood of MAFLD in CAD patients, since these patients have decreased appetite and lower body mass index (BMI). On the other hand, female gender, having diabetes, high waist circumference, high triglyceride levels, and high ALT levels increase the probability of MAFLD in CAD patients.

🔗 https://doi.org/10.34172/aim.2024.36

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❇️ انتشار #مقاله جدید با وابستگی کوتار💠 Sleep profiles in epilepsy patients undergoing monotherapy and polytherapy: A comparative cross-sectional study👥 Alireza Arvin, Morvarid Taebi, Zahra Khazaeipour, Arezu Najafi, Abbas Tafakhori, Sakineh Ranji-Bourachaloo, Hamed Amirifard*

📔 Epilepsy & Behavior (Q2)

🗓 April 2024🗂 Original research📄 Abstract: Sleep disturbances commonly reported among epilepsy patients have a reciprocal relationship with the condition; While epilepsy and anti-seizure medications (ASMs) can disrupt sleep structure, disturbed sleep can also exacerbate the frequency of seizures. This study explored subjective sleep disturbances and compared sleep profiles in patients who underwent ASM monotherapy and polytherapy. We enrolled 176 epilepsy patients who completed a structured questionnaire containing demographic and clinical information and the Persian versions of the Pittsburgh Sleep Quality Index (PSQI), Insomnia Severity Index (ISI), Epworth Sleepiness Scale (ESS), and Patient Health Questionnaire-9 (PHQ-9) to evaluate sleep quality, insomnia, excessive daytime sleepiness (EDS), and depressive symptoms, respectively. Chi-square and Mann-Whitney U tests were employed to analyze the association between variables, and logistic regression analysis was conducted to identify factors predicting sleep disturbances. Comparative analysis of mono/polytherapy groups revealed a significantly higher prevalence of insomnia and EDS among patients on polytherapy compared to monotherapy. However, no significant difference was found in sleep quality between the two groups. Logistic regression analysis revealed that a depressive mood serves as a robust predictor for sleep issues, whereas treatment type did not emerge as an independent predictor of sleep disturbances. Our findings suggest that an increased number of ASMs does not inherently result in a higher incidence of sleep issues. Therefore, multiple ASMs may be prescribed when necessary to achieve improved seizure control. Furthermore, this study underscores the importance of comprehensive management that addresses seizure control and treating affective symptoms in individuals with epilepsy.

🔗 https://doi.org/10.1016/j.yebeh.2024.109799

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❇️ انتشار #مقاله جدید با وابستگی کوتار💠 Machine Learning for prediction of violent behaviors in schizophrenia spectrum disorders: a systematic review👥 Mohammadamin Parsaei, Alireza Arvin, Morvarid Taebi, Homa Seyedmirzaei, Giulia Cattarinussi, Fabio Sambataro, Alessandro Pigoni, Paolo Brambilla, Giuseppe Delvecchio*

📔 Frontiers in Psychiatry (Q2)

🗓 March 2024🗂 Review📄 Abstract: Schizophrenia spectrum disorders (SSD) can be associated with an increased risk of violent behavior (VB), which can harm patients, others, and properties. Prediction of VB could help reduce the SSD burden on patients and healthcare systems. Some recent studies have used machine learning (ML) algorithms to identify SSD patients at risk of VB. In this article, we aimed to review studies that used ML to predict VB in SSD patients and discuss the most successful ML methods and predictors of VB. We performed a systematic search in PubMed, Web of Sciences, Embase, and PsycINFO on September 30, 2023, to identify studies on the application of ML in predicting VB in SSD patients. We included 18 studies with data from 11,733 patients diagnosed with SSD. Different ML models demonstrated mixed performance with an area under the receiver operating characteristic curve of 0.56-0.95 and an accuracy of 50.27-90.67% in predicting violence among SSD patients. Our comparative analysis demonstrated a superior performance for the gradient boosting model, compared to other ML models in predicting VB among SSD patients. Various sociodemographic, clinical, metabolic, and neuroimaging features were associated with VB, with age and olanzapine equivalent dose at the time of discharge being the most frequently identified factors. ML models demonstrated varied VB prediction performance in SSD patients, with gradient boosting outperforming. Further research is warranted for clinical applications of ML methods in this field.

🔗 https://doi.org/10.3389/fpsyt.2024.1384828

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✳️ فراخوان شورای اجرایی ۱۴۰۳🔸 دو عنصر اساسی در ساختار مرکز تحقیقات میان‌رشته‌ای کاربردی ارتوپدی (COTAR) وجود دارد: کمیته‌هایی که از اعضای هیئت علمی تشکیل شده‌اند و به شورای پژوهشی معروف هستند و شورای اجرایی که از پژوهشگران ارشد و رئیس مرکز تشکیل شده‌اند. تمامی موفقیت‌ها و پیشرفت‌هایی که مرکز تاکنون داشته است، نتیجه‌ی تلاش‌ها و حضور مداوم این دو رکن بوده است.

🔹 اکنون با آغاز سال جدید، قرار است شورای اجرایی نیز اعضای جدید خود را بشناسد. به همین منظور، از تمامی دانشجویان و فارغ‌التحصیلان کوتاری دغدغه‌مند دعوت می‌شود تا با ثبت‌نام از طریق فرم زیر، آمادگی خود را جهت عضویت در این شورا اعلام نمایند:
🔗 https://forms.formool.ir/6hl69

❓ جهت اطلاع از سازوکار، نقش‌ها و وظایف اعضای شورای اجرایی، لطفا سند زیر را مطالعه نمایید:
https://cotar.tums.ac.ir/InfrastructureDoc

⏰ مهلت ثبت‌نام: سه شنبه ۲۹ اسفند ۱۴۰۲، ساعت ۲۳:۵۹

🌱 امید است که با تداوم این چرخه، پرقدرت به مسیر ادامه دهیم.

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❇️ انتشار #مقاله جدید با وابستگی کوتار💠 Distal femoral osteotomy and patellar tendon advancement for the treatment of crouch gait in patients with bilateral spastic cerebral palsy👥 Mohammad Hossein Nabian, Shayan Abdollah Zadegan, Cindy Mallet, Yamile Neder, Brice Ilharreborde, Anne Laure Simon, Ana Presedo*

📔 Gait & Posture (Q1)

🗓 March 2024🗂 Original research📄 Abstract: Crouch gait, or flexed knee gait, represents a common gait pattern in patients with spastic bilateral cerebral palsy (CP). Distal femoral extension and/or shortening osteotomy (DFEO/DFSO) and patellar tendon advancement (PTA) can be considered as viable options when knee flexion contractures are involved. Better outcomes have been reported after a combination of both, independently of the presence of knee extensor lag. In this study, we evaluated the clinical and kinematic outcomes of these procedures. We reviewed a cohort of 52 limbs (28 patients) who were treated for crouch gait by DFEO/DFSO alone (group 1, n = 15) or DFEO/DFSO + PTA (group 2, n = 37) as a part of single event multilevel surgery (SEMLS). The mean age at surgery was 14 years, and the mean follow-up time was 18 months. The physical examination data and three-dimensional standardized gait analysis were collected and analyzed before the surgery and postoperatively. Overall knee range of motion improved in all limbs. The knee flexion decreased significantly in both groups at initial, mid, and terminal stance. Hip flexion significantly decreased in mid-stance for limbs in group 2. Both clinical and gait parameters were most improved in limbs who underwent DFEO/DFSO + PTA. Increased pelvic tilt was observed in both groups after surgery. Although DFEO/DFSO alone was successful in correcting knee flexion contractures, PTA has helped to improve knee extensor lag and knee extension during gait.

🔗 https://doi.org/10.1016/j.gaitpost.2024.02.019

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❇️ انتشار #مقاله جدید با وابستگی کوتار💠 Non-coding RNAs as potential therapeutic targets for receptor tyrosine kinase signaling in solid tumors: current status and future directions👥 Aysan Moeinafshar, Mohammad Nouri, Nima Shokrollahi, Mahdi Masrour, Amirmohammad Behnam, Sahand Tehrani Fateh, Hossein Sadeghi, Mohammad Miryounesi & Mohammad-Reza

📔 Cancer Cell International (Q1)

🗓 January 2024🗂 Review📄 Abstract: This review article presents an in-depth analysis of the current state of research on receptor tyrosine kinase regulatory non-coding RNAs (RTK-RNAs) in solid tumors. RTK-RNAs belong to a class of non-coding RNAs (nc-RNAs) responsible for regulating the expression and activity of receptor tyrosine kinases (RTKs), which play a critical role in cancer development and progression. The article explores the molecular mechanisms through which RTK-RNAs modulate RTK signaling pathways and highlights recent advancements in the field. This include the identification of potential new RTK-RNAs and development of therapeutic strategies targeting RTK-RNAs. While the review discusses promising results from a variety of studies, encompassing in vitro, in vivo, and clinical investigations, it is important to acknowledge the challenges and limitations associated with targeting RTK-RNAs for therapeutic applications. Further studies involving various cancer cell lines, animal models, and ultimately, patients are necessary to validate the efficacy of targeting RTK-RNAs. The specificity of ncRNAs in targeting cellular pathways grants them tremendous potential, but careful consideration is required to minimize off-target effects, the article additionally discusses the potential clinical applications of RTK-RNAs as biomarkers for cancer diagnosis, prognosis, and treatment. In essence, by providing a comprehensive overview of the current understanding of RTK-RNAs in solid tumors, this review emphasizes their potential as therapeutic targets for cancer while acknowledging the associated challenges and limitations.

🔗 https://doi.org/10.1186/s12935-023-03203-2

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