ketamine:
1-NMDA
2-⬆️Arterial pressure & tachycardia
3- bronchial muscle dilated
4- eye movement
5- ⬆️salivation .....to give atropine
6- hallucinations ......to give midazolam
7- good analgesia
8- ⬆️ICP
9 sever hypotension &bleeding
10- does:
analgesia ....》 0.5mg/kg
sedation ....》1mg/kg

ETOMIDATE:
1- GABA receptor
2 -⬆️ICP
♡ Adverse Effects:
1- Injection site pain.
2- Eye movement.
3- Skeletal muscle movements.
4. Suppression of synthesis of .
5- Nausea and vomiting .
Contraindications:
1- Airway obstruction
2- Porphyria
3- Adrenal insufficiency
4- Long - term infusion in ICU.

thiopental:
1- GABA receptor (inhibitors).
2- Myocardial contractility is depressed and peripheral vasodilatation.
3- ⬇️arterial pressure & hypotension
4- ⬇️heart rate
5- does:
onset less than 30sec.
maintenance 25-100mg IV .
duration 10-15 min.

Adverse effects:
1- Hypersensitivity reactions
2- Coughing , laryngospasm
3- Bronchospasm ( histamine release ) 4- Respiratory depression and apnoea 5- Hypotension , myocardial depression 6- Tachycardia , arrhythmias.

Contraindications :
1- Airway obstruction
2- Previous hypersensitivity
3- Status asthmatics
4- Porphyria

#propofol:-
1- soybean oil ( lipid) - glycerol (proten)- egglecithin .

a- allergic
b- infection
بدرجه حراره الغرفه 6 ساعات .
بدرجه حراره الثلاجه 24ساعه .
2- GABA receptor (inhibitors).
a- deep coma .
b- intubation.
3- a- pain on injection.
b- involuntary movement.
4 - a- C.V.S ......》 vasodalation .....》 sever hypotension .
b- cardiac depression.......》 Brady cardia.
5- respiratory a- good bronchodilator and apnea .
b- asthma .
6- statusepilepsia more than 30sec.ولمده نصف ساعه
7- completion
ICU .....》pediatric , HF , Hepatic failure .
infusion >4mg /kg /h......》 24h .....》propofol infusion syndrome ......》 metabolic acidosis.
8- metabolism liver .
9- does:
sedation......》 1mg/kg .
hypnotic ......》 2-3mg/kg .

#سؤال2 واجب / ماهي انواع او تقسيم NOn- depolarizing ؟