🟢ح ندير قناة فيها فويسات شارح فيهن الجينيرال من البداية للنهاية بالكامل استفادو منهن طلبة ال49 وكانن سبب في نجاح الكثير.

وكل مرة نضيفو فيها كورس ،

يقعد عندنا محاضرات أساسية ومراجعة للمنهج برضو

وأنت خلي الفويسات للمراجعة السريعة وقتهن مش طويل.

بمجرد ما ننزلو اخر محاضرة ح ننزل شيت فيه ال E/W الخاص بالجينيرال بالكامل و حيجيك منه أسئلة، و ح نزلو أسئلة و ننطلقو في الباقي بداية ب NSAIDs

و ح نجهزو ال TB استعدادا للTBL (مزال ما اعلنوش على موعده).

?Explain why (Distribution) ?1-explain the characteristic of drug that bound to plasma protein ✅the bound form is inactive form ->decrease the action of drug The bound form not metabolized or eliminated by kidney. The bound form lead to prolong the…

?Explain why (Distribution)

?1-explain the characteristic of drug that bound to plasma protein

✅the bound form is inactive form ->decrease the action of drug
The bound form not metabolized or eliminated by kidney.
The bound form lead to prolong the duration of the drug action.
The bound form has low distribution volume.

?2-the drugs are distributed to the lung more than the skin

✅b/c lung is highly perfused organ.

?3-in liver cirrhosis the action of drug is increase

✅b/c 1- ⬇️protein synthesis-> ⬆️free form of drug -> ⬆️action.
2- in cirrhosis->⬇️ metabolism & hepatic drug elimination -> ⬆️action and duration of drug.

?4-polar drugs can not cross BBB in healthy person ,but can cross BBB in pateint with meningitis.

✅b/c meningitis lead to temporally disruption in BBB layers make even the polar drug easy to cross BBB .

?5-if u take warfarin then u kake aspirin , this ⬆️risk of bleeding.

✅b/c aspirin Displace the warfarin from plasma protein ->⬆️ free form of warfarin->⬆️action ->⬆️risk of bleeding.

Also small dose of aspirin has antiplatelet effect. May ⬆️risk of bleeding.

?6- in pateint with acute MI or Ulcerative colitis ,may be need to increase the dose of basic drugs.

✅b/c in this cases ⬆️ α1 acid glycoprotein -> bound th basic drug &⬇️the free form of basic drugs like propranolol.

?7-if u take T4 then u kake aspirin , this ⬆️risk of Thyrotoxicosis.

✅b/c aspirin Displace the T4 from plasma protein ->⬆️ free form of T4->⬆️action ->⬆️risk of Thyrotoxicosis.

?8-if u take Tolbutamide then u kake aspirin , this ⬆️risk of Hypoglycemia.

✅b/c aspirin Displace the Tolbutamide from plasma protein ->⬆️ free form of Tolbutamide->⬆️action ->⬆️risk of Hypoglycemia.

?9-Hemodialysis is useless in management of toxicity with drug that has large volume of distribution.

✅b/c the majority of drug distributed in body tissue & hemodialysis has benefit only if the drug distributed only in the plasma

?10- Some drugs remain only in Plasma compartment

✅b/c the drug is too large to pass through the slit junction of capillaries and trapped within the plasma

has high Mw or bound to pp.

?11- Some drugs remain only in ECF and can not pass into ICF

✅b/c the drug is small to pass through capillaries into interstitial fluid but it is Hydrophilic -> can not cross lipid membrane

?12-Some drugs are found in all body fluid 

✅b/c the drug is small  to pass through capillaries into interstitial fluid & it is lipophilic -> can cross lipid membrane

في موضوع ال Distribution

لما تحسب ال V.d و تطلعلك إجابة

مرات ما تلقش الاجابة ف الخيارات
لكن تلقى لي يقابلها ف body fluids

برضو اادكتورة ركزت فيها

?هاشتاق محاضرات الجينيرال ،،الشيتات ،،، الأسئلة
كل شيء نكملوه ح نضيفوه للهاشتاق هذا

? Lectures

Principles

?Gen. Pharmacology 1️⃣

Part I Part II

Part III Part IV

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?Sheets

?Gen.Pharmacology1️⃣

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?Explain Why

Gen Pharmacology1️⃣
https://t.me/pharmousa/4408
https://t.me/pharmousa/4409
https://t.me/pharmousa/4410

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***🔴***Explain why ***🟢*** General Pharmacology 1 ***🔵***1-Explain the benefit of Evaluation of new drugs. ***✅***to study the safety and the efficacy of new drugs essential to get marketing approval before using by the human. ***🔵***2-explain the benefit of Phase 0 in Evaluation…

لما نكملو الجينيرال كله،،، ح نحطوهن في شيت واحد كلهن،،

توا كل شيت نكملوه ننزلو الأسئلة تتعرف عليهن

وركز على أن في بعض الأسئلة الE/W مرات يكونن في صورة نقاط ،،،ح توضح معانا أكثر كل ما نقدمو في المنهج..

هذين لما تكمل الشيت الأول تقراهن

اتعرف على طريقة ال E/W امتاع الشيت الأول

صدقني لما تقرا وتفهم كامل الشيت مش ح ياخذن منك عشر دقايق