How Non-steroidal anti-inflammatory drugs (NSAID) like aspirin cause peptic ulcer ?.
Core physiology book *📚 *answer:
- These inhibit synthesis of prostaglandins from arachidonic acid.
- Since prostaglandins inhibit HCL synthesis and increase mucus
secretion, then chronic use of aspirin, which inhibits its formation from arachidonic acid, results in increased HCL secretion and decreasedmucus production causing peptic ulcer.

Functions of HCL in stomach :
- Kills ingested bacteria
- Activates pepsinogen to pepsin & allows its action
- Maintains iron in the ferrous state to facilitate its absorption
- Facilitates absorption of calcium
- Stimulates flow of bile (by stimulating release of secretin)

النسخه الاحدث 🔼🔼🔼
والشكر لمن أرسله د رؤى عصام

Core physiology volume one

https://t.me/tafrighat/4397