Researchers from Stanford University, Princeton University, and Google Deepmind have introduced CRISPR-GPT, a tool that merges CRISPR technology with advanced LLMs such as GPT-4. This integration facilitates the automation of gene-editing experiments, enabling precise genomic modifications with reduced complexity. The unique aspect of CRISPR-GPT lies in its ability to synthesize domain-specific knowledge with LLMs’ computational efficiency, streamlining the experimental design process in ways previously unachievable with general-purpose LLMs.
CRISPR-GPT employs a methodology integrating CRISPR technology with computational models based on LLMs, specifically GPT-4. The system utilizes a comprehensive dataset that includes CRISPR system efficiencies and guide RNA (gRNA) sequences, which are vital for optimizing the selection and design processes. The framework of CRISPR-GPT consists of multiple modules that automate tasks such as CRISPR system selection, gRNA design, and method delivery recommendations. Each module is powered by LLMs that have been fine-tuned with domain-specific biological data to ensure high accuracy and efficiency in gene-editing experiments.

bioRxiv

CRISPR-GPT: An LLM Agent for Automated Design of Gene-Editing Experiments

The introduction of genome engineering technology has transformed biomedical research, making it possible to make precise changes to genetic information. However, creating an efficient gene-editing system requires a deep understanding of CRISPR technology…

https://www.biorxiv.org/content/10.1101/2024.04.25.591003v1?utm_source=www.airesearchinsights.com&utm_medium=newsletter&utm_campaign=marktechpost-ai-newsletter-crispr-gpt-for-innovative-gene-editing-enhancements-meta-ai-introduces-cyberseceval-2-pytorch-introduces-executorch-alpha

bioRxiv

CRISPR-GPT: An LLM Agent for Automated Design of Gene-Editing Experiments

The introduction of genome engineering technology has transformed biomedical research, making it possible to make precise changes to genetic information. However, creating an efficient gene-editing system requires a deep understanding of CRISPR technology…

مقاله ای بسیار مهم در ارتباط با روش crispr-cas9 با یادگیری عمیق و مدلهای LLMای مثل Chat-GPT (با تشکر از آقای زکی زاده)👇

A very important paper that links deep learning with crispr-cas9 entitled as "CRISPR-GPT: An LLM Agent for Automated Design of Gene-Editing Experiments" (Thanks to Mr.zakizadeh) 👇

A very beautiful video entitled "But what is GDP, visual introduction to transformer, chapter 5, Deep learning (2.1M visits up to 3 May 2024 just one month after its publication which is astonishing)

https://youtu.be/wjZofJX0v4M?feature=shared

YouTube

But what is a GPT? Visual intro to transformers | Chapter 5, Deep Learning

Unpacking how large language models work under the hood Early view of the next chapter for patrons: https://3b1b.co/early-attention Special thanks to these supporters: https://3b1b.co/lessons/gpt#thanks To contribute edits to the subtitles, visit https:…

A very beautiful video entitled as "But what is GDP, visual introduction to transformer, chapter 5, Deep learning" to make you familiar with transformers (2.1M visits up to 3 May 2024 just one month after its publication which is astonishing) 👇

ویدیویی بسیار جالب و پر بازدید راجع به روش GPT و مفهوم Transformers که در مدت کوتاه یک ماه اخیر (تا امروز ۱۴ فروردین ۱۴۰۳) 2.1 میلیون بازدید خورده است که نرخ رشد محیرالعقولی است. 👇

شعاری بسیار عجیب در دانشگاه نیویورک آمریکا (از رودخانه تا دریا -یعنی همان رود اردن تا دریای مدیترانه- فلسطین آزاد باید گردد)